It's weird to me to see roguelikes called "comfy." Not only are most of them quite difficult, but you can quickly die from one mistake. I've started playing Nethack over the last few days, and so far, every game has ended with me stepping into a room and being suddenly and immediately murdered.>>76
Harvest Moon GB? I've played that one, and it is indeed pretty relaxing. I think my very favorite HM games are 64 and Friends of Mineral Town for GBA. It's been a long time since I played it, but I remember Magical Melodies on the Gamecube being quite good, too.
I always wanted to try Rune Factory. The combination of Harvest Moon with more conventional fantasy/RPG stuff seems really interesting.